Background

Pathogenic bacteria are widespread in nature and can cause infections and various complications, thereby posing a severe risk to public health. Therefore, simple, rapid, sensitive, and cost-effective methods must be developed to detect pathogenic bacteria. Biosensors are prominent platforms for detecting pathogenic bacteria owing to their high sensitivity, specificity, repeatability, and stability. With the development of nanotechnology, graphene oxide (GO) has been increasingly introduced into the construction of fluorescent biosensors to enhance their performance owing to its unique physicochemical properties.

Results

This review systematically summarizes the development of GO-based fluorescent biosensors for the detection of pathogenic bacteria. First, we introduce the functionalization and modification of GO. The design and signal amplification strategies for GO-based fluorescent biosensors are also discussed. Finally, we explore the challenges and new perspectives associated with this field, with the aim of facilitating the development of GO-based fluorescent sensing technologies to prevent the spread of multidrug-resistant bacteria.

Significance

This review will aid in the development of high-performance biosensors for pathogenic bacterial assays.

中文翻译：

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基于氧化石墨烯的荧光生物传感器用于病原菌检测

 背景

致病菌在自然界中广泛存在，可引起感染和各种并发症，从而对公共卫生构成严重风险。因此，必须开发简单、快速、灵敏且具有成本效益的方法来检测病原菌。生物传感器因其高灵敏度、特异性、可重复性和稳定性而成为检测病原菌的重要平台。随着纳米技术的发展，氧化石墨烯 （GO） 因其独特的物理化学性质而越来越多地被引入荧光生物传感器的构建中，以提高其性能。

 结果

本文系统总结了基于 GO 的荧光生物传感器在病原菌检测中的应用进展。首先，我们介绍了 GO 的功能化和修饰。还讨论了基于 GO 的荧光生物传感器的设计和信号放大策略。最后，我们探讨了与该领域相关的挑战和新观点，旨在促进基于 GO 的荧光传感技术的发展，以防止多重耐药细菌的传播。

 意义

本综述将有助于开发用于病原菌测定的高性能生物传感器。