Balancing efficient fractionation with the structural intactness of lignin in lignocellulose pretreatment remains challenging. An innovative strategy with selective lignin solubilization/extraction/stabilization was developed to efficiently fractionate high-quality carbohydrates and well-preserve lignin from wheat straw employing a bio-based ternary deep eutectic solvent comprising dimethyl isosorbide/ethylene glycol/oxalic acid. Ultrahigh pretreatment efficiency (90.7 %), delignification rate (92.2 %), and cellulose recovery (88.4 %) were demonstrated in 37 min. Furthermore, excellent enzymatic digestibility (91.9 %), conversion of inhibitor-free carbohydrate hydrolysates to microbial lipid (8.3 g/100.0 g wheat straw), and lignin with good UV-blocking performance were obtained. The mechanistic insights into delignification were elucidated through Hansen solubility theory, revealing that the lower relative energy difference, strong hydrogen bonding cohesion, and ethylene glycol incorporation enabled efficient utilization of the sugar platform without compromising the structural intactness of lignin. This lignin solubilization-oriented strategy complements green and efficient pretreatment methods for lignocellulose that target holistic valorization and contribute to closed-loop biorefineries.

中文翻译：

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一种生物基低共熔溶剂，具有增强的木质素溶解度，用于小麦秸秆分馏和全组分利用


在木质素纤维素预处理中平衡高效分馏与木质素的结构完整性仍然具有挑战性。开发了一种选择性木质素溶解/提取/稳定的创新策略，采用包含二甲基异山梨酯/乙二醇/草酸的生物基三元深共熔溶剂，从小麦秸秆中有效分离高质量碳水化合物并保存木质素。在 37 分钟内表现出超高的预处理效率 （90.7 %）、脱木素率 （92.2 %） 和纤维素回收率 （88.4 %）。此外，获得了优异的酶消化率 （91.9 %）、无抑制剂碳水化合物水解物向微生物脂质的转化（8.3 g/100.0 g 小麦秸秆）和具有良好的紫外线阻隔性能的木质素。通过 Hansen 溶解度理论阐明了对脱木素作用的机理见解，揭示了较低的相对能量差、强氢键内聚力和乙二醇掺入使糖平台能够有效利用，而不会影响木质素的结构完整性。这种以木质素增溶为导向的策略补充了木质素纤维素的绿色高效预处理方法，这些方法以整体价值化为目标，有助于闭环生物精炼厂。