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Exploring the medicinal potential of Dendrobium: Uncovering the spatial distribution of flavonoids and alkaloids in 15 species of Dendrobium using MALDI-MSI
Scientia Horticulturae ( IF 3.9 ) Pub Date : 2024-10-20 , DOI: 10.1016/j.scienta.2024.113738 Yingdan Yuan, Chutian Li, Sumei Qiu, Can Yang, Runyang Zhou, Sian Liu
Dendrobium , the second largest genus in the Orchidaceae family, has been regarded as a valuable medicinal plant throughout Chinese history. Secondary metabolites present in the stem of Dendrobium , including alkaloids and flavonoids, confer significant pharmacological effects such as anti-inflammatory, antibacterial, immunomodulatory, antitumor, and antioxidant properties. To our knowledge, this study is the first to apply matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) technology to comprehensively identify the spatial distribution of secondary metabolites, particularly flavonoids and alkaloids, in the mature stems of 15 common Dendrobium species. By analyzing the matching scores and relative concentrations of compounds, 20 flavonoids and 19 alkaloids with high identification credibility were identified, along with 4 sesquiterpenoid compounds. Their spatial distributions and compositions were analyzed, and the results revealed that despite the similar structural basis of the stems in the 15 Dendrobium species, significant differences existed in the distribution of secondary metabolites among different species. Flavonoids and alkaloids with different medicinal effects exhibited certain specific distribution patterns; for instance, flavonoids with antioxidant effects were mostly concentrated in the outer circle of thin-walled cells of Dendrobium stems, whereas those with antitumor effects were found in higher concentrations in the central areas of some Dendrobium species than in the periphery. Alkaloids with antitumor properties typically exhibited a higher concentration in peripheral thin-walled cells than in central regions. Furthermore, statistical analysis was conducted on the content of secondary metabolites with different effects among the 15 Dendrobium species to identify species with greater medicinal potential in terms of antioxidant and antitumor effects. The findings of this study not only enhance our understanding of the distribution patterns of flavonoids and alkaloids within Dendrobium stems but also offer valuable insights for the medicinal development and quality assessment of Dendrobium .
更新日期：2024-10-20
Scientia Horticulturae ( IF 3.9 ) Pub Date : 2024-10-20 , DOI: 10.1016/j.scienta.2024.113738 Yingdan Yuan, Chutian Li, Sumei Qiu, Can Yang, Runyang Zhou, Sian Liu
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