Resolving metabolic heterogeneity in patients with type 2 diabetes mellitus (T2DM) gives them access to precision medicine. Despite ethnic diversity in pathophysiological processes in individuals with T2DM, studies on subtypes of diabetes related to clinical characteristics in Asians are insufficient. This study aims to identify metabolic patterns in middle-aged patients with T2DM in Republic of Korea (Korea) and determine the incidence of diabetes-related complications according to patterns. We analyzed 6,603 patients with T2DM aged 30 to 64 who visited three centers of general hospital in Korea. Three metabolic patterns were derived: Obesity and Hypertension pattern (OH-P), Liver Function-related HyperGlycemia pattern (LFHG-P), and Decreased Kidney Function pattern (DKF-P). The highest tertile of the OH-P score was associated with an increased risk of peripheral vascular disease compared to the lowest tertile (HR = 1.26, 95% CI = 1.02-1.57). The highest tertile of the LFHG-P score was associated with an increased risk of myocardial infarction (HR = 1.79, 95% CI = 1.13-2.82) and atrial fibrillation (HR = 1.54, 95% CI = 1.07-2.23). No association with complications was found in the DKF-P. This study suggests the need for proper management and treatment according to metabolic patterns in patients with T2DM.

中文翻译：

---

韩国 2 型糖尿病患者代谢模式的鉴定及其与糖尿病相关并发症的关联


解决 2 型糖尿病 （T2DM） 患者的代谢异质性问题，使他们能够获得精准医疗。尽管 T2DM 患者病理生理过程存在种族差异，但对与亚洲人临床特征相关的糖尿病亚型的研究不足。本研究旨在确定韩国 （Korea） 中年 T2DM 患者的代谢模式，并根据模式确定糖尿病相关并发症的发生率。我们分析了 6,603 名年龄在 30 至 64 岁之间的 T2DM 患者，这些患者访问了韩国综合医院的三个中心。得出 3 种代谢模式：肥胖和高血压模式 （OH-P） 、肝功能相关高血糖模式 （LFHG-P） 和肾功能下降模式 （DKF-P）。与最低的三分位数相比，OH-P 评分的最高三分位数与外周血管疾病的风险增加相关 （HR = 1.26,95% CI = 1.02-1.57）。LFHG-P 评分的最高三分位数与心肌梗死 （HR = 1.79,95% CI = 1.13-2.82） 和心房颤动 （HR = 1.54,95% CI = 1.07-2.23） 的风险增加相关。在 DKF-P 中未发现与并发症的关联。这项研究表明，需要根据 T2DM 患者的代谢模式进行适当的管理和治疗。