We analyzed clinical manifestations, antifungal susceptibility, and treatment outcomes of cutaneous sporotrichosis in Thailand during 2018–2022. The study included 49 patients whose mean age was 58.7 (SD 16.9) years; 65.3% were female and 34.7% male. A history of cat exposure was reported in 32 (65.3%) patients who had a significantly higher prevalence of upper extremity lesions than did those without cat contact (90.6% vs. 41.7%; adjusted odds ratio 18.9 [95% CI 3.2–92.9]). Among patients >60 years of age, lesions were more likely to be nonpustular than for patients <60 years of age (82.1% vs. 52.4%; p = 0.033). All 9 isolates tested for antifungal drug susceptibility exhibited an itraconazole MIC of <1 μg/mL. Oral itraconazole monotherapy was effective; the median time-to-cure was 180 days (interquartile range 141–240 days). Physicians should heighten their awareness of potential sporotrichosis causes, particularly when a history of animal contact exists.

我们分析了 2018-2022 年泰国皮肤孢子丝菌病的临床表现、抗真菌药敏试验和治疗结果。该研究包括 49 名患者，平均年龄为 58.7 （SD 16.9） 岁;65.3% 为女性，34.7% 为男性。据报道，32 例 （65.3%） 患者有猫暴露史，这些患者的上肢病变患病率显著高于没有猫接触的患者 （90.6% vs. 41.7%;校正比值比 18.9 [95% CI 3.2-92.9]）。在 >60 岁患者中，病变比 <60 岁患者更可能是非脓疱性的 （82.1% vs. 52.4%;p = 0.033）。所有 9 株抗真菌药物敏感性检测的分离株均显示伊曲康唑 MIC 为 <1 μg/mL。口服伊曲康唑单药治疗有效;中位治愈时间为 180 天 （四分位距 141-240 天）。医生应提高对潜在孢子丝菌病病因的认识，尤其是当存在动物接触史时。