As a nondestructive and ultrasensitive technique, surface-enhanced Raman spectroscopy (SERS) has captivated the attention of the global scientific community for over 50 years. Among the various spectroscopic techniques derived from SERS, shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) stands as a cutting-edge advancement. The innovative and versatile core–shell nanoparticle structures used in SHINERS have emerged as an ideal platform for interfacial research, offering high sensitivity and broad applicability across diverse materials and single-crystal surfaces. Consequently, SHINERS has seen widespread adoption in pivotal fields, such as interface chemistry, electrocatalysis, biomedicine, materials, and food safety. In this Perspective, we outline the evolutionary journey of SHINERS, delve deep into its applications in fundamental research for interface characterization and catalysis, and explore its practical utility in critical areas of food safety and biomedicine analysis. Additionally, we map out the prospective trajectory and future milestones that await SHINERS as it continues to revolutionize the landscape of scientific exploration.

中文翻译：

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壳层分离纳米颗粒增强拉曼光谱：迈向高灵敏度和广泛适用性


作为一种无损和超灵敏的技术，表面增强拉曼光谱 （SERS） 50 多年来一直吸引着全球科学界的关注。在 SERS 衍生的各种光谱技术中，壳分离纳米颗粒增强拉曼光谱 （SHINERS） 是一项前沿进步。SHINERS 中使用的创新和多功能核壳纳米颗粒结构已成为界面研究的理想平台，可在各种材料和单晶表面中提供高灵敏度和广泛的适用性。因此，SHINERS 已在界面化学、电催化、生物医学、材料和食品安全等关键领域得到广泛采用。在这个视角中，我们概述了 SHINERS 的进化历程，深入研究了它在界面表征和催化基础研究中的应用，并探讨了它在食品安全和生物医学分析关键领域的实际应用。此外，我们还规划了等待 SHINERS 的前瞻性轨迹和未来里程碑，因为它将继续彻底改变科学探索的格局。