Organic ferroelectrics show great applications in the fields of biomedicine, including disease treatment, biosensors, and tissue engineering. Organosilicon pharmaceutical intermediates generally include chiral centers and have satisfying biosafety, biocompatibility, or even biodegradability, which provide versatile platforms for the design of ferroelectricity. However, their academic values in ferroelectricity have long been long overlooked. Here, we demonstrated the ferroelectric properties of 4-acetoxy-azacyclic butanone (4-AA), a key synthetic organosilicon-based intermediate of carbapenem drugs. This compound undergoes a 222F2-type ferroelectric–ferroelastic phase transition at 326 K. As an organic piezoelectric material, 4-AA can produce reactive oxygen species when subjected to ultrasonic vibrations. Combined with its desirable biocompatibility, this material may contribute to antimicrobial and wound healing, tumor treatment, etc. This work will provide inspiration for the discovery of multifunctional biomedical ferroelectric materials as well as their related application prospects.

中文翻译：

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观察碳青霉烯类中间体中的铁电性可通过超声生成活性氧


有机铁电体在生物医学领域显示出巨大的应用，包括疾病治疗、生物传感器和组织工程。有机硅医药中间体通常包括手性中心，具有令人满意的生物安全性、生物相容性，甚至生物降解性，为铁电性的设计提供了多功能平台。然而，它们在铁电性方面的学术价值长期以来一直被忽视。在这里，我们展示了 4-乙酰氧基氮杂环丁酮 （4-AA） 的铁电特性，4-乙酰氧基氮杂环丁酮 （4-AA） 是碳青霉烯类药物的关键合成有机硅基中间体。该化合物在 222 K 时发生 326F2 型铁电-铁弹性相变。作为一种有机压电材料，4-AA 在受到超声波振动时会产生活性氧。结合其理想的生物相容性，这种材料可能有助于抗菌和伤口愈合、肿瘤治疗等。这项工作将为多功能生物医用铁电材料的发现及其相关应用前景提供灵感。