A simple and effective strategy for the construction of disulfide-substituted oxazole derivatives from amides, ynals, and acetyl disulfides via a Lewis acid-promoted three-component reaction has been reported. In addition, this reaction possesses other unique advantages, such as transition-metal-free catalysis, the production of disulfides, good functional group tolerance, and good regioselectivity.

中文翻译：

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路易斯酸促进三组分环化构建二噻噁唑衍生物


已经报道了一种通过 Lewis 酸促进的三组分反应从酰胺、亚醛和乙酰二硫化物构建二硫键取代的二硫键取代的恶唑衍生物的简单而有效的策略。此外，该反应还具有其他独特的优势，如无过渡金属催化、产生二硫化物、良好的官能团耐受性和良好的区域选择性。