As a promising cancer treatment modality that has emerged, photodynamic / photothermal therapy can harness antitumor immunity by triggering immunogenic cell death in addition to direct cell ablation. However, the efficacy of this phototherapy is always limited due to the hypoxic tumor microenvironment, and the induccd immune stimulation is insufficient to achieve satisfactory cancer eradication. We herein address the above issues by nanoconfined in situ mineralization of manganese oxide (MnO2) guided with an oligopeptide as template. The synthetic nanocomposites can be co-assembled efficiently with the photosensitiser through π-π stacking interactions. Crucially, the mineralised MnO2 composition catalytically decomposes tumor-derived hydrogen peroxide to alleviate the hypoxic microenvironment, thereby improving the efficacy of the photosensitiser in ROS generation. In the murine model of 4 T1 xenograft tumors, the fabricated nanotherapeutics elicited robust antitumor immune responses and boost immunogenic phototherapy toward malignant tumors.

中文翻译：

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寡肽模板引导的纳米限制原位矿化纳米治疗药物促进了自给自足的免疫原性光疗


作为一种已经出现的有前途的癌症治疗方式，光动力/光热疗法除了直接细胞消融外，还可以通过触发免疫原性细胞死亡来利用抗肿瘤免疫。然而，由于缺氧的肿瘤微环境，这种光疗的疗效总是有限的，诱导免疫刺激不足以实现令人满意的癌症根除。我们在这里通过以寡肽为模板引导的氧化锰 （MnO2） 的纳米限制原位矿化来解决上述问题。合成纳米复合材料可以通过π-π堆叠相互作用与光敏剂有效地共组装。至关重要的是，矿化的 MnO2 组合物催化分解肿瘤衍生的过氧化氢以减轻缺氧微环境，从而提高光敏剂在 ROS 生成中的功效。在 4 个 T1 异种移植肿瘤的小鼠模型中，制造的纳米治疗药物引发了强大的抗肿瘤免疫反应，并促进了对恶性肿瘤的免疫原性光疗。