Biomimetic carriers utilizing cells and cellular components revolutionize the field of anticancer drug delivery systems. Existing reviews in this field have predominantly approached biomimetic drug delivery systems by focusing on either the carrier or the payload. However, recognizing the intrinsic inseparability of the drug and the biomimetic carrier is imperative, as their mutual influences decisively shape the drug delivery system. This review delineated the recent progress in biomimetic carriers for antitumor therapeutics from a distinct perspective, concentrating on the relationship between the drug and the carrier. The relationship involves drug-loading mode, the loading position, and the mechanism of drug-release strategies. This review highlighted the crucial roles of drug loading morphologies and loading positions in enhancing the efficiency of carrier delivery and overcoming barriers to cancer treatment. Additionally, innovative strategies for controlled drug release from biomimetic carriers were summarized, and an extensive discussion on the future prospects and potential challenges in this field was provided.

中文翻译：

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用于抗癌的仿生药物递送：关注药物与仿生载体之间的关系


利用细胞和细胞成分的仿生载体彻底改变了抗癌药物递送系统领域。该领域的现有综述主要通过关注载体或有效载荷来接近仿生药物递送系统。然而，必须认识到药物和仿生载体的内在不可分割性，因为它们的相互影响决定性地塑造了药物递送系统。本文从不同的角度阐述了抗肿瘤治疗仿生载体的最新进展，重点介绍了药物与载体之间的关系。这种关系涉及载药模式、载药位置和药物释放策略的机制。本综述强调了药物负载形态和负载位置在提高载体递送效率和克服癌症治疗障碍方面的关键作用。此外，总结了从仿生载体中控制药物释放的创新策略，并对该领域的未来前景和潜在挑战进行了广泛讨论。