Oocyte maturation arrest is a leading cause of female infertility. However, the genetic variables remain largely unknown. In oocytes, the activation of anaphase-promoting complex/cyclosome (APC/C) is a critical step in the transition from meiosis I to meiosis II. However, the causal relationship between variants in APC/C components and female infertility has not been completely investigated.

中文翻译：

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APC12 的纯合错义变异导致卵母细胞减数分裂中期 I 停滞和女性不育


卵母细胞成熟停滞是女性不孕症的主要原因。然而，遗传变量在很大程度上仍然未知。在卵母细胞中，后期促进复合物/睫状体 （APC/C） 的激活是从减数分裂 I 过渡到减数分裂 II 的关键步骤。然而，APC/C 成分变异与女性不孕症之间的因果关系尚未得到完全研究。