Dry eye disease (DED) is increasingly prevalent, with inflammation playing a crucial role in its pathogenesis. Severe cases of DED result in significant ocular discomfort and visual impairment due to damage and loss of ocular surface epithelial cells. The precise mechanisms underlying the loss of these epithelial cells remain a subject of ongoing research and debate. Programmed cell death (PCD) mechanisms, including pyroptosis, apoptosis, and necroptosis, are known to be critical in maintaining ocular surface homeostasis and responding to stressors in DED. The concept of PANoptosis, which integrates elements of various PCD pathways, has been implicated in the development of numerous systemic diseases, including infections, cancer, neurodegenerative, and inflammatory conditions. It also provides novel insights into the inflammatory processes underlying DED. This review highlights the crosstalk of PCD pathways in DED, particularly the significance of PANoptosis in ocular inflammation and its potential as a therapeutic target for more effective interventions.

中文翻译：

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干眼症中的细胞死亡途径：对眼表炎症的见解


干眼症 （DED） 越来越普遍，炎症在其发病机制中起着至关重要的作用。严重的 DED 病例由于眼表上皮细胞的损伤和丢失而导致严重的眼部不适和视力障碍。这些上皮细胞丢失的确切机制仍然是一个正在进行的研究和辩论的主题。已知程序性细胞死亡 （PCD） 机制，包括焦亡、细胞凋亡和坏死性凋亡，对于维持眼表稳态和响应 DED 中的应激源至关重要。全细胞移植的概念整合了各种 PCD 通路的元素，与许多全身性疾病的发展有关，包括感染、癌症、神经退行性和炎症性疾病。它还为了解 DED 背后的炎症过程提供了新的见解。本综述强调了 DED 中 PCD 通路的串扰，特别是 PANoptosis 在眼部炎症中的重要性及其作为更有效干预的治疗靶点的潜力。