Protein kinase A (PKA) is a basophilic kinase implicated in the modulation of many cell-signaling and physiological processes. PKA also contributes to cancer-relevant events such as growth factor action, cell cycle control, cell migration and tumor metabolism. Germline and somatic mutations in PKA, gene amplifications, and chromosome rearrangements that encode kinase fusions, are linked to a growing number of malignant neoplasms. Mislocalization of PKA by exclusion from A-Kinase Anchoring Protein (AKAP) signaling islands further underlies cancer progression. This article highlights the influence of AKAP signaling and local kinase action in selected hallmarks of cancer. We also feature the utility of kinase inhibitor drugs as frontline and future anti-cancer therapies.

中文翻译：

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癌症中的蛋白激酶 A 和局部信号传导。


蛋白激酶 A （PKA） 是一种嗜碱性激酶，与许多细胞信号转导和生理过程的调节有关。PKA 还有助于癌症相关事件，例如生长因子作用、细胞周期控制、细胞迁移和肿瘤代谢。PKA 中的种系和体细胞突变、基因扩增和编码激酶融合的染色体重排与越来越多的恶性肿瘤有关。通过排除 A 激酶锚定蛋白 （AKAP） 信号岛而错误定位 PKA 进一步是癌症进展的基础。本文重点介绍了 AKAP 信号转导和局部激酶作用对癌症选定标志物的影响。我们还重点介绍了激酶抑制剂药物作为一线和未来抗癌疗法的效用。