Antibacterial hydrogels have generated significant interest for their potential therapeutic applications. Ozone (O₃) is recognized for its antibacterial, anti-inflammatory, immunomodulatory, and anti-hypoxic properties, along with its minimal residual impact. However, the development of sustained O₃-release antibacterial hydrogels has been challenging due to the low solubility and short lifespan of ozone. We present an ozone-loaded emulsion hydrogel (ozonegel), which encapsulates ozonized oil within a nanoclay-poly(methacryloxyethyl sulfobetaine) supramolecular network. This adhesive, self-healing ozonegel achieves high ozone loading (91.3 mmol/kg) and releases O₃ and reactive oxygen species (ROS) over 36 h. It demonstrates broad antibacterial and anti-inflammatory effects, promoting wound healing. The remarkable properties of ozonegels suggest significant potential for advanced biomedical applications.

中文翻译：

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用于持续臭氧释放的自修复粘合水凝胶：增强抗菌性能并改善伤口愈合


抗菌水凝胶对其潜在的治疗应用产生了浓厚的兴趣。臭氧 （O₃） 以其抗菌、抗炎、免疫调节和抗缺氧特性以及最小的残留影响而著称。然而，由于臭氧的溶解度低且寿命短，持续释放 O ₃ 释放抗菌水凝胶的开发一直具有挑战性。我们提出了一种负载臭氧的乳化水凝胶 （ozonegel），它将臭氧化油封装在纳米粘土-聚（甲基丙烯酰磺基甜菜碱）超分子网络中。这种胶粘剂、自修复臭氧凝胶可实现高臭氧负荷 （91.3 mmol/kg），并在 36 小时内释放 O₃ 和活性氧 （ROS）。它具有广泛的抗菌和抗炎作用，促进伤口愈合。臭氧凝胶的卓越特性表明在高级生物医学应用方面具有巨大潜力。