Diffuse alveolar hemorrhage (DAH) is a form of hemoptysis caused by disruption of the alveolar-capillary basement membrane causing alveolar bleeding. Inhalation of cocaine and other sympathomimetic agents are described as one of many pathologic causes. We describe what is to the author's knowledge the first reported case of DAH caused by inhalation of bupropion, a norepinephrine-dopamine reuptake inhibitor, which was successfully treated with systemic steroids. This case adds a novel agent to the known pathologic causes of DAH and introduces a novel form of bupropion toxicity, which should be considered as a cause in cases of DAH in the appropriate clinical context. The case also highlights the potential for further research into the pathologic interactions of bupropion at the alveolar basement membrane.

中文翻译：

---

安非他酮吸入引起的弥漫性肺泡出血。


弥漫性肺泡出血 （DAH） 是一种由肺泡毛细血管基底膜破坏引起的咯血，导致肺泡出血。吸入可卡因和其他拟交感神经药物被描述为许多病理原因之一。我们描述了据作者所知的第一例报告的由吸入安非他酮引起的 DAH 病例，安非他酮是一种去甲肾上腺素-多巴胺再摄取抑制剂，该病例已成功使用全身性类固醇治疗。本病例在 DAH 的已知病理原因中增加了一种新的药物，并引入了一种新型的安非他酮毒性，在适当的临床背景下，应将其视为 DAH 病例的一个原因。该病例还强调了进一步研究安非他酮在肺泡基底膜上的病理相互作用的潜力。