Food Protein-Induced Enterocolitis (FPIES) is a non-IgE mediated GI food allergy characterized by delayed, protracted vomiting, accompanied by lethargy and pallor, usually 1-4 hours following ingestion of the food allergen. The pathophysiology of FPIES remains unknown and currently there are no diagnostic biomarkers available to assess disease activity or its resolution. Over the last two decades, FPIES has become increasingly recognized in both pediatric and adult patients. Forty years later after the initial FPIES description, the first international classification of diseases (ICD-10) code for FPIES was established and the first international consensus guidelines for diagnosis and management of FPIES was published. On June 22, 2022, the National Institute of Allergy and Infectious Diseases (NIAID) held its first virtual multidisciplinary workshop on FPIES. Various clinical and translational aspects of FPIES, as well as the important areas of unmet needs were discussed as priorities for future research during this 2-day virtual workshop. The following report provides a summary of content of the workshop, including updated literature on the topic areas, as well as providing a critical commentary on the state of FPIES.

中文翻译：

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食物蛋白诱导的小肠结肠炎综合征 （FPIES） 的现状和未来方向：NIAID 研讨会报告。


食物蛋白诱导的小肠结肠炎 （FPIES） 是一种非 IgE 介导的胃肠道食物过敏，其特征是延迟、长时间的呕吐，伴有嗜睡和苍白，通常在摄入食物过敏原后 1-4 小时发生。FPIES 的病理生理学仍然未知，目前没有可用于评估疾病活动或其消退的诊断生物标志物。在过去的二十年里，FPIES 在儿科和成人患者中越来越受到认可。在最初的 FPIES 描述后 40 年后，建立了 FPIES 的第一个国际疾病分类 （ICD-10） 代码，并发布了第一个 FPIES 诊断和管理的国际共识指南。2022 年 6 月 22 日，美国国家过敏和传染病研究所 （NIAID） 举办了首届关于 FPIES 的虚拟多学科研讨会。在为期 2 天的虚拟研讨会上，讨论了 FPIES 的各种临床和转化方面，以及未满足需求的重要领域，作为未来研究的优先事项。以下报告提供了研讨会内容摘要，包括有关主题领域的更新文献，并提供了对 FPIES 状态的批判性评论。