An organocatalytic asymmetric vinylogous Michael/oxa-Michael tandem reaction between β,γ-unsaturated pyrazoleamides and isatin-derived β,γ-unsaturated ketoesters has been developed with excellent regio-, diastereo-, and enantioselectivities. The methodology provides an effective approach to construct enantiomerically pure 3,4′-pyranyl spirooxindole derivatives containing three contiguous chiral centers. Moreover, the transformations of the chiral products, including the removal and reduction of the pyrazole group, have been investigated.

中文翻译：

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β，γ-不饱和酰胺与阿丁衍生的β，γ-不饱和α酮酯之间的不对称乙烯基 Michael/Oxa-Michael 串联反应


β，γ-不饱和吡唑酰胺和β，γ-不饱和酮酯之间的有机催化不对称乙烯基 Michael/oxa-Michael 串联反应已被开发出来，具有优异的区域、非对映和对映选择性。该方法提供了一种构建对映体纯的 3,4′-吡喃基螺吲哚衍生物的有效方法，其中包含三个连续的手性中心。此外，已经研究了手性产物的转化，包括吡唑基团的去除和还原。