Laminarin mainly consists of fucoidan, a unique, naturally active sulfate polysaccharide. Laminarin is known for its outstanding multiple bioactives, but its role in lactation remains largely unknown. Therefore, this study aimed to explore the influence of maternal intake of laminarin on lactation and infant health in a porcine model. A total of 20 sows of parity 6.85 ± 0.88 with similar comprehensive scores were randomly allocated to two dietary treatments to receive a basal diet with/without supplementary laminarin. We showed that maternal intake of laminarin improved the antioxidant capacity and intestinal barrier function of the offspring, alleviated the inflammatory response, and facilitated infant growth and health. Mechanistically, maternal consumption of laminarin significantly modified the metabolite profiles of colostrum and milk. We also demonstrated in a vitro study that coniferyl aldehyde, a representative differential milk metabolite, enhanced antioxidant capacity and tight junction protein expression levels in intestinal epithelial cells. In summary, maternal intake of laminarin facilitated offspring health and growth by fortifying milk metabolites.

中文翻译：

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产妇摄入海带多糖通过强化初乳和牛奶的代谢物谱来改善婴儿的生长和健康


海带多糖主要由岩藻多糖组成，褐藻多糖是一种独特的、天然活性的硫酸盐多糖。海带多糖以其出色的多种生物活性而闻名，但它在哺乳中的作用在很大程度上仍然未知。因此，本研究旨在探讨猪模型中母亲摄入海带多糖对泌乳和婴儿健康的影响。共有 20 头胎次为 6.85 ± 0.88 且综合评分相似的母猪被随机分配到两种日粮处理组，接受基础日粮加/不补充海带多糖。结果表明，母体摄入海带多糖提高了后代的抗氧化能力和肠道屏障功能，缓解了炎症反应，促进了婴儿的生长发育和健康。从机制上讲，母体食用海带多糖显着改变了初乳和牛奶的代谢物谱。我们还在体外研究中证明，松麻醛是一种具有代表性的牛奶差异代谢物，可增强肠上皮细胞中的抗氧化能力和紧密连接蛋白表达水平。总之，母体摄入海带多糖通过强化牛奶代谢物促进后代的健康和生长。