Over the last two decades, manganese(I) carbonyl complexes have been widely investigated as carbon monoxide releasing molecules (CORMs) to transfer small quantities of CO to biological targets to have beneficial impacts such as preventing ischemia reperfusion injury and reducing organ transplant rejection. Furthermore, these complexes exhibit beneficial anti-coagulative, anti-apoptotic, anti-inflammatory, and anti-proliferative properties. Owing to their highly controlled substitution chemistry and oxidative durability, Mn(I) carbonyl moieties were combined with a wide range of auxiliary ligands, including biomolecules. This review focused on tri- and tetracarbonyl Mn(I) complexes that were exposed to light, changed the redox status, or underwent thermal activation to release carbon monoxide. Kinetic parameters, stability in the dark, number of CO release equivalents, CO detection tools, and the nature of solvents used in the studies are reported and tabulated. An overview of all the previously published Mn(I) CORMs is specifically provided to define the method of action of these promising biologically active compounds and discuss their possible therapeutic applications in relation to their CO-releasing and biocompatibility characteristics.

中文翻译：

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过去二十年报道的 Mn（I） 羰基化合物作为一氧化碳释放分子的全面调查


在过去的二十年里，锰（）羰基配合物作为一氧化碳释放分子 （CORM） 被广泛研究，可将少量 CO 转移到生物靶标，从而产生有益的影响，例如预防缺血再灌注损伤和减少器官移植排斥反应。此外，这些复合物表现出有益的抗凝血、抗凋亡、抗炎和抗增殖特性。由于其高度受控的取代化学和氧化耐久性，Mn（） 羰基部分与包括生物分子在内的多种辅助配体结合。本综述重点介绍了暴露在光线下、改变氧化还原状态或经历热活化以释放一氧化碳的三羰基和四羰基 Mn（） 配合物。报告并制成表格，包括动力学参数、避光稳定性、一氧化碳释放当量的数量、一氧化碳检测工具以及研究中使用的溶剂的性质。专门提供了所有先前发表的 Mn（） CORM 的概述，以定义这些有前途的生物活性化合物的作用方法，并讨论它们与其 CO 释放和生物相容性特性相关的可能治疗应用。