Corynebacterium glutamicum, a well-studied industrial model microorganism, has garnered widespread attention due to its ability for producing amino acids with a long history. In recent years, research efforts have been increasingly focused on exploring its potential for producing various organic acids beyond amino acids. Organic acids, which are characterized by their acidic functional groups, have diverse applications across industries such as food, agriculture, pharmaceuticals, and biobased materials. Leveraging advancements in metabolic engineering and synthetic biology, the metabolic pathways of C. glutamicum have been broadened to facilitate the production of numerous high-value organic acids. This review summarizes the recent progress in metabolic engineering for the production of both amino acids and other organic acids by C. glutamicum. Notably, these acids include, amino acids (lysine, isoleucine, and phenylalanine), TCA cycle-derived organic acids (succinic acid, α-ketoglutaric acid), aromatic organic acids (protocatechuate, 4-amino-3-hydroxybenzoic acid, anthranilate, and para-coumaric acid), and other organic acids (itaconic acid and cis, cis-muconic acid).

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谷氨酸棒状杆菌的代谢工程：释放其作为有机酸生产关键细胞工厂平台的潜力


谷氨酸棒状杆菌是一种经过充分研究的工业模式微生物，因其产生具有悠久历史的氨基酸的能力而受到广泛关注。近年来，研究工作越来越集中在探索其生产氨基酸以外的各种有机酸的潜力。有机酸以其酸性官能团为特征，在食品、农业、制药和生物基材料等行业中有多种应用。利用代谢工程和合成生物学的进步，谷氨酸梭菌的代谢途径已被拓宽，以促进许多高价值有机酸的产生。本文总结了谷氨酸梭菌生产氨基酸和其他有机酸的代谢工程研究的最新进展。值得注意的是，这些酸包括氨基酸（赖氨酸、异亮氨酸和苯丙氨酸）、TCA 循环衍生的有机酸（琥珀酸、α-酮戊二酸）、芳香族有机酸（原儿茶酸、4-氨基-3-羟基苯甲酸、邻氨基苯甲酸酯和对香豆酸）和其他有机酸（衣康酸和顺式、顺式粘康酸）。