NKX3.1-expressing intermediate Basal-B cells represent a transient basal stem cell state during prostate regeneration, inflammation and cancer initiation. Remarkably, activation of JAK/STAT signaling is essential in regulating expansion and differentiation of Basal-B-like cells during prostate inflammation, identifying this signaling pathway as a potential therapeutic target in prostatitis associated with increased Basal-B signature.

中文翻译：

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在前列腺再生和疾病中具有激活 JAK/STAT 信号传导的中间细胞


表达 NKX3.1 的中间体基础 B 细胞代表前列腺再生、炎症和癌症发作过程中的瞬时基础干细胞状态。值得注意的是，JAK/STAT 信号通路的激活对于前列腺炎症期间基底 B 样细胞的扩增和分化至关重要，将该信号通路确定为与基础 B 特征增加相关的前列腺炎的潜在治疗靶点。