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Prospective observational study and mechanistic evidence showing lipolysis of circulating triglycerides worsens hypertriglyceridemic acute pancreatitis
The Journal of Clinical Investigation ( IF 13.3 ) Pub Date : 2024 , DOI: 10.1172/jci184785 Prasad Rajalingamgari, Biswajit Khatua, Megan J. Summers, Sergiy Kostenko, Yu-Hui H. Chang, Mohamed Elmallahy, Arti Anand, Anoop Narayana Pillai, Mahmoud Morsy, Shubham Trivedi, Bryce McFayden, Sarah Jahangir, Christine L.H. Snozek, Vijay P. Singh
The Journal of Clinical Investigation ( IF 13.3 ) Pub Date : 2024 , DOI: 10.1172/jci184785 Prasad Rajalingamgari, Biswajit Khatua, Megan J. Summers, Sergiy Kostenko, Yu-Hui H. Chang, Mohamed Elmallahy, Arti Anand, Anoop Narayana Pillai, Mahmoud Morsy, Shubham Trivedi, Bryce McFayden, Sarah Jahangir, Christine L.H. Snozek, Vijay P. Singh
BACKGROUND. While most hypertriglyceridemia is asymptomatic, hypertriglyceridemia-associated acute pancreatitis (HTG-AP) can be more severe than AP of other etiologies. The reasons underlying this are unclear. We thus examined whether lipolytic generation of nonesterified fatty acids (NEFAs) from circulating triglycerides (TGs) could worsen clinical outcomes.
中文翻译:
前瞻性观察研究和机制证据表明循环甘油三酯的脂肪分解会加重高甘油三酯血症性急性胰腺炎
背景。 虽然大多数高甘油三酯血症是无症状的,但高甘油三酯血症相关急性胰腺炎 (HTG-AP) 可能比其他病因的 AP 更严重。这背后的原因尚不清楚。因此,我们检查了循环甘油三酯 (TGs) 中脂解生成非酯化脂肪酸 (NEFAs) 是否会使临床结局恶化。
更新日期:2025-01-03
中文翻译:

前瞻性观察研究和机制证据表明循环甘油三酯的脂肪分解会加重高甘油三酯血症性急性胰腺炎
背景。 虽然大多数高甘油三酯血症是无症状的,但高甘油三酯血症相关急性胰腺炎 (HTG-AP) 可能比其他病因的 AP 更严重。这背后的原因尚不清楚。因此,我们检查了循环甘油三酯 (TGs) 中脂解生成非酯化脂肪酸 (NEFAs) 是否会使临床结局恶化。