Antimicrobial resistance is one of the most urgent global health threats, especially in the post-pandemic era. Antimicrobial peptides (AMPs) offer a promising alternative to traditional antibiotics, driving growing interest in recent years. dbAMP is a comprehensive database offering extensive annotations on AMPs, including sequence information, functional activity data, physicochemical properties and structural annotations. In this update, dbAMP has curated data from over 5200 publications, encompassing 33,065 AMPs and 2453 antimicrobial proteins from 3534 organisms. Additionally, dbAMP utilizes ESMFold to determine the three-dimensional structures of AMPs, providing over 30,000 structural annotations that facilitate structure-based functional insights for clinical drug development. Furthermore, dbAMP employs molecular docking techniques, providing over 100 docked complexes that contribute useful insights into the potential mechanisms of AMPs. The toxicity and stability of AMPs are critical factors in assessing their potential as clinical drugs. The updated dbAMP introduced an efficient tool for evaluating the hemolytic toxicity and half-life of AMPs, alongside an AMP optimization platform for designing AMPs with high antimicrobial activity, reduced toxicity and increased stability. The updated dbAMP is freely accessible at https://awi.cuhk.edu.cn/dbAMP/. Overall, dbAMP represents a comprehensive and essential resource for AMP analysis and design, poised to advance antimicrobial strategies in the post-pandemic era.

中文翻译：

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dbAMP 3.0：后疫情时代多肽抗菌活性和结构注释的更新资源


抗微生物药物耐药性是全球最紧迫的健康威胁之一，尤其是在后疫情时代。抗菌肽 （AMP） 为传统抗生素提供了一种有前途的替代品，近年来推动了人们的兴趣日益浓厚。dbAMP 是一个全面的数据库，提供了有关 AMP 的广泛注释，包括序列信息、功能活性数据、物理化学性质和结构注释。在此次更新中，dbAMP 整理了来自 5200 多篇出版物的数据，包括来自 3534 种生物体的 33,065 种 AMP 和 2453 种抗菌蛋白。此外，dbAMP 利用 ESMFold 来确定 AMP 的三维结构，提供超过 30,000 个结构注释，有助于为临床药物开发提供基于结构的功能见解。此外，dbAMP 采用分子对接技术，提供 100 多个对接复合物，有助于深入了解 AMP 的潜在机制。AMPs 的毒性和稳定性是评估其作为临床药物潜力的关键因素。更新后的 dbAMP 引入了一种用于评估 AMP 溶血毒性和半衰期的有效工具，以及用于设计具有高抗菌活性、毒性更低和稳定性更高的 AMP 的 AMP 优化平台。更新后的 dbAMP 可在 https://awi.cuhk.edu.cn/dbAMP/ 上免费访问。总体而言，dbAMP 代表了 AMP 分析和设计的全面且必不可少的资源，有望在后大流行时代推进抗菌策略。