BitterDB (http://bitterdb.agri.huji.ac.il) was introduced in 2012 as a central resource for information on bitter-tasting molecules and their receptors, and was updated in 2019. The information in BitterDB is used for tasks such as exploring the bitter chemical space, choosing suitable ligands for experimental studies, analyzing receptors’ selectivity and promiscuity, and developing machine learning predictors for taste. Here, we describe a major upgrade of the database, including significant increase in content as well as new features. BitterDB now holds over 2200 bitter molecules. For ∼700 molecules, at least one associated bitter taste receptor (TAS2R) is reported. The overall number of ligand-TAS2R associations is now close to 1800. BitterDB is extended to a total of 66 species (including dog, birds, fishes and primates). Following advances in computational structure prediction by AlphaFold and related methods, and the experimental determination of TAS2R structures by cryo-electron microscopy, BitterDB provides links to available structures of TAS2Rs.

中文翻译：

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BitterDB：2024 年苦味配体和味觉受体更新


BitterDB （http://bitterdb.agri.huji.ac.il） 于 2012 年推出，作为有关苦味分子及其受体信息的中心资源，并于 2019 年更新。BitterDB 中的信息用于探索苦味化学空间、为实验研究选择合适的配体、分析受体的选择性和混杂性以及开发味道的机器学习预测器等任务。在这里，我们介绍了数据库的重大升级，包括内容的显著增加以及新功能。BitterDB 现在拥有 2200 多个苦味分子。对于 ∼700 个分子，至少报道了一个相关的苦味受体 （TAS2R）。配体-TAS2R 关联的总数现在接近 1800 个。BitterDB 扩展到总共 66 个物种（包括狗、鸟、鱼和灵长类动物）。随着 AlphaFold 和相关方法计算结构预测的进步，以及通过冷冻电子显微镜对 TAS2R 结构的实验测定，BitterDB 提供了 TAS2R 可用结构的链接。