Fluoroquinolones are an important component of anti-tuberculosis treatment and identifying fluoroquinolone resistance is essential. We present the first survey of fluoroquinolone resistance in England from sequencing of over 16,000 unselected isolates. Fluoroquinolone resistance was 1.4% overall and 23.9% in multidrug-resistant TB. Routine sequencing allows resistance surveillance and should be widely adopted.

中文翻译：

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2017-2023 年英格兰结核分枝杆菌复合体分离株全基因组测序药物预测的氟喹诺酮类药物耐药率


氟喹诺酮类药物是抗结核治疗的重要组成部分，确定氟喹诺酮类药物耐药性至关重要。我们从 16,000 多种未经选择的分离株的测序中提出了英格兰首次氟喹诺酮类药物耐药性调查。氟喹诺酮类药物耐药性总体为 1.4%，耐多药结核病为 23.9%。常规测序可进行耐药性监测，应广泛采用。