Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clinical challenge. Throughout the process of liver metastases formation, immune cells play a pivotal role, particularly in the pre-metastatic and metastatic niches within the liver. Immune cells establish extensive and intricate interactions with tumor cells and other components in the liver, collectively promoting and sustaining the growth of liver metastases. Despite the limited efficacy of existing therapeutic modalities against some advanced liver metastases, novel immune-based treatment approaches are continuously being explored and validated. Building on the systematic elucidation of the immunosuppressive characteristics of liver metastases, we explored the potential of novel immunotherapies applicable to patients with liver metastases from multiple dimensions.

中文翻译：

---

塑造肝转移中转移前和转移性生态位的免疫动力学：从分子机制到治疗策略


肝转移常见于各种恶性肿瘤的晚期，是一项重大的临床挑战。在肝转移形成的整个过程中，免疫细胞起着关键作用，特别是在肝脏内的转移前和转移性生态位中。免疫细胞与肿瘤细胞和肝脏中的其他成分建立广泛而复杂的相互作用，共同促进和维持肝转移的生长。尽管现有治疗方式对某些晚期肝转移的疗效有限，但基于免疫的新型治疗方法正在不断探索和验证。在系统阐明肝转移免疫抑制特性的基础上，我们从多个维度探索了适用于肝转移患者的新型免疫疗法的潜力。