Itaconate is a metabolite produced by macrophages upon infection and acts as an antimicrobial molecule. In this issue of Cancer Cell, Lin et al. find that itaconate produced by tumor-associated macrophages is taken up by cancer cells via the transporter solute carrier family 13 member 3 (SLC13A3), promoting resistance to immune checkpoint inhibitors.

中文翻译：

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衣康酸盐促进意想不到的肿瘤免疫逃逸机制


衣康酸盐是巨噬细胞在感染后产生的代谢物，起抗菌分子的作用。在本期《癌细胞》中，Lin 等人发现肿瘤相关巨噬细胞产生的衣康酸盐通过转运蛋白溶质载体家族 13 成员 3 （SLC13A3） 被癌细胞吸收，促进对免疫检查点抑制剂的耐药性。