Itaconate is a metabolite produced by macrophages upon infection and acts as an antimicrobial molecule. In this issue of Cancer Cell, Lin et al. found that itaconate produced by tumor-associated macrophages is taken up by cancer cells via the transporter solute carrier family 13 member 3 (SLC13A3), promoting resistance to immune checkpoint inhibitors.

中文翻译：

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衣康酸盐促进意想不到的肿瘤免疫逃逸机制


衣康酸盐是巨噬细胞在感染后产生的代谢物，起抗菌分子的作用。在本期《癌细胞》杂志上，Lin 等人发现，肿瘤相关巨噬细胞产生的衣康酸盐通过转运蛋白溶质载体家族 13 成员 3 （SLC13A3） 被癌细胞吸收，促进对免疫检查点抑制剂的耐药性。