While photothermal sterilization offers significant advantages over antibiotics for treating surgical site infections, its application is limited by side effects caused by excessive heat. To address this dilemma, this study focuses on the often-overlooked factor of temperature inhomogeneity within irradiated regions, which impacts photothermal efficacy. We propose a solution termed “bacterial photothermal dressing”. In this approach, tannic acid (TA) first attaches to bacteria or biofilm and subsequently captures surrounding Fe^III ions to form a close-fitting Fe^IIITA dressing in situ. For comparison, a conventional photothermal sterilization method is established by directly administering Fe^IIITA nanoparticles to infected sites. The bacterial photothermal dressing approach allows for bacterial elimination at much lower temperatures, minimizing heat-related side effects. Moreover, the acidic microenvironment within the biofilm can trigger the gradual release of TA, permitting continuous antiseptic and anti-inflammatory effects. This sustained activity enhances antibacterial efficacy and helps prevent secondary infection following photothermal treatment. Consequently, this approach significantly accelerates wound healing by improving bactericidal efficiency and reducing inflammatory responses.

中文翻译：

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用于感染病灶低温灭菌的细菌敷料的原位构建


虽然光热灭菌在治疗手术部位感染方面比抗生素具有显着优势，但其应用受到过热引起的副作用的限制。为了解决这一困境，本研究重点关注照射区域内经常被忽视的温度不均匀性因素，该因素会影响光热效率。我们提出了一种称为“细菌光热敷料”的解决方案。在这种方法中，单宁酸 （TA） 首先附着在细菌或生物膜上，随后捕获周围的 Fe^III 离子，在原位形成紧密贴合的 Fe^IIITA 敷料。为了进行比较，通过将 Fe^IIITA 纳米颗粒直接施用到感染部位来建立常规的光热灭菌方法。细菌光热敷料方法允许在低得多的温度下消除细菌，从而最大限度地减少与热相关的副作用。此外，生物膜内的酸性微环境可以触发 TA 的逐渐释放，从而实现持续的防腐和抗炎作用。这种持续的活性增强了抗菌功效，并有助于防止光热处理后的继发感染。因此，这种方法通过提高杀菌效率和减少炎症反应来显着加速伤口愈合。