4-Alkylation of pyridines has been achieved by a photocatalyzed three-component reaction of an olefin, an aryloxyacetic acid, and cyanopyridine using Ir[dF(CF₃)ppy]₂(dtbbpy)PF₆ as a photocatalyst. In this way, a new type of 4-alkylpyridines bearing aryl and aryloxy substituents on the phenyl was accessed with potential pharmaceutical value. In addition to mild reaction conditions, the method has several other advantages, including a multicomponent one-pot protocol, good functional group tolerance, and easy amplification of the reaction scale. The reaction mechanism has been clarified by control experiments and computation of the reaction energy profile.

中文翻译：

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可见光介导的三组分脱羧偶联反应合成 4-烷基吡啶


吡啶的 4-烷基化是通过烯烃、芳氧基乙酸和氰基吡啶的光催化三组分反应实现的，使用 Ir[dF（CF₃）ppy]₂（dtbbpy）PF₆ 作为光催化剂。通过这种方式，一种在苯基上带有芳基和芳氧基取代基的新型 4-烷基吡啶被获得，具有潜在的药学价值。除了温和的反应条件外，该方法还具有其他几个优点，包括多组分一锅方案、良好的官能团耐受性以及易于扩增反应规模。通过对照实验和反应能量曲线的计算阐明了反应机理。