A method for the efficient synthesis of chiral cycloallylalcohols has been developed, achieving excellent yields and enantioselectivities (>99% conversion, turnover number of ≤50 000, and >99% ee). This approach accommodates a variety of cycloalkenones with different aryl substituents and is tolerant of a broad range of functional groups. The synthetic utility of this method has been demonstrated through gram-scale synthesis and subsequent transformations into diverse enantioenriched oxygen-containing compounds.

中文翻译：

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铱催化的环烯酮化学和对映选择性氢化以获得手性环烯丙基醇


已经开发了一种高效合成手性环烯丙基醇的方法，实现了优异的产率和对映选择性（>99% 转化率、≤ 50 000 的周转数和 >99% ee）。这种方法适用于具有不同芳基取代基的多种环烯酮，并且耐受广泛的官能团。该方法的合成效用已通过克级合成和随后转化为多种富含对映体的含氧化合物来证明。