A two-step strategy has been established for the enantioselective synthesis of 4-aminoquinolines possessing axial chirality. This approach involves a chiral phosphoric acid-catalyzed cycloaddition, followed by a DDQ oxidation step. The method offers efficient access to a variety of 1,1′-biaryl-2,2′-amino alcohol derivatives in excellent yields and enantioselectivities (up to 98% yield and 93% ee). Furthermore, the synthetic transformation of the products was also investigated.

中文翻译：

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通过环加成和中心到轴向手性转换构建轴向手性 4-氨基喹啉


已经建立了一种两步策略，用于对映选择性合成具有轴向手性的 4-氨基喹啉。该方法包括手性磷酸催化的环加成反应，然后是 DDQ 氧化步骤。该方法以优异的产量和对映体选择性（高达 98% 的产量和 93% 的 ee）提供了对各种 1,1′-联芳基-2,2′-氨基醇衍生物的高效获取。此外，还研究了产物的合成转化。