As a broad-spectrum antimicrobial material, ZnO nanoparticles (NPs) offer a novel approach to infected wounds in the clinic; however, it is very necessary to improve the antimicrobial performance of ZnO to satisfy the clinic requirements. In this work, a new antimicrobial hybrid ZnO@PDA/GL13K was prepared by attaching the antimicrobial GL13K peptide on the surface of ZnO NPs via polydopamine (PDA) as a covalent bonding agent, which can enhance the reactive oxygen species (ROS) production and damage the cell wall, showing superior antimicrobial efficacy. Besides, the ZnO@PDA/GL13K hybrid can promote the healing of bacterial infected wounds, with the wound area only remaining 1.8% on day 9, about 2 times smaller than that of the ZnO group. Moreover, ZnO@PDA/GL13K also showed good biocompatibility, and no side effect on normal tissue and organs was found, implying that the antimicrobial hybrid may possess prospective application in biomedical fields.

中文翻译：

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抗菌 GL13K 肽修饰的 ZnO 纳米颗粒治疗细菌感染


作为一种广谱抗菌材料，ZnO 纳米颗粒 （NPs） 为临床感染的伤口提供了一种新的方法;然而，为了满足临床需求，提高 ZnO 的抗菌性能是非常必要的。在本工作中，通过聚多巴胺 （PDA） 作为共价键剂将抗菌 GL13K 肽附着在 ZnO NPs 表面，制备了一种新的抗菌杂交 ZnO@PDA/GL13K，可以增强活性氧 （ROS） 的产生并破坏细胞壁，显示出优越的抗菌效果。此外，ZnO@PDA/GL13K 杂交体可促进细菌感染伤口愈合，第 9 天伤口面积仅保留 1.8%，比 ZnO 组小约 2 倍。此外，ZnO@PDA/GL13K 也显示出良好的生物相容性，对正常组织和器官没有副作用，这意味着抗菌杂交种可能在生物医学领域具有前瞻性应用。