A novel method for the two-step synthesis of α-boryl-α-substituted allylboronates from propyne is described. These allylboronates are prepared by the Co-catalyzed 1,1-diboration reaction of propyne with B₂pin₂, followed by the base-mediated alkylation reaction of 1,1-di(boryl)propene at the α-position. Computational studies revealed the origins of observed reactivity and selectivity in the base-mediated alkylation reaction. The resulting α-boryl-α-methyl-allylboronate is applied to the allylation of aldehydes, which gives homoallylic alcohols with a trisubstituted alkene moiety.

中文翻译：

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Propyne 合成 α-硼基-α-取代的烯丙基硼酸盐


描述了一种从丙炔两步合成 α-硼基-α-取代烯丙基硼酸盐的新方法。这些烯丙基硼酸盐是通过丙炔与 B₂针₂ 的共催化 1,1-二硼化反应制备的，然后是 1,1-二（硼基）丙烯在 α 位的碱介导的烷基化反应。计算研究揭示了在碱基介导的烷基化反应中观察到的反应性和选择性的来源。所得的 α-硼基-α-甲基烯丙基硼酸酯被应用于醛的烯丙基化，得到具有三取代烯烃部分的均烯丙基醇。