In recent years, radical-mediated cross-coupling reactions have emerged as a compelling strategy for achieving a rich diversity in molecular topologies under benign conditions. However, the inherent high reactivity of radicals presents considerable challenges in controlling reaction pathways and selectivity, which often results in a limited range of substrates and a constrained reaction profile. Given the capacity of visible-light photoredox catalysis to generate a wide variety of reactive radicals and radical ions in a controlled manner and the propensity of copper complexes toward radical species, we envisaged that the synergy between chiral copper catalysts and photoactive catalysts would pave the way for developing innovative strategies. This integration is poised to unlock a broad spectrum of enantioselective multicomponent radical cross-coupling reactions.

中文翻译：

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光催化遇铜催化：不对称多组分自由基交叉偶联反应的新机遇


近年来，自由基介导的交叉偶联反应已成为在良性条件下实现分子拓扑结构丰富多样性的令人信服的策略。然而，自由基固有的高反应性在控制反应途径和选择性方面带来了相当大的挑战，这通常会导致底物范围有限和反应曲线受限。鉴于可见光光氧化还原催化以受控方式产生多种反应性自由基和自由基离子的能力以及铜配合物对自由基物种的倾向，我们设想手性铜催化剂和光活性催化剂之间的协同作用将为开发创新策略铺平道路。这种整合有望解锁广泛的对映选择性多组分自由基交叉偶联反应。