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Acoustofluidic tweezers via ring resonance
Science Advances ( IF 11.7 ) Pub Date : 2024-11-13 , DOI: 10.1126/sciadv.ads2654
Xianchen Xu, Ke Jin, Kaichun Yang, Ruoyu Zhong, Mingyuan Liu, Wesley Collyer, Shivam Jain, Ying Chen, Jianping Xia, Junfei Li, Shujie Yang, Earl H. Dowell, Tony Jun Huang

Ring resonator (RR) devices are closed-loop waveguides where waves circulate only at the resonant frequencies. They have been used in sensor technology and optical tweezers, but controlling micron-scale particles with optical RR tweezers is challenging due to insufficient force, short working distances, and photodamage. To overcome these obstacles, an acoustofluidic RR-based tweezing method is developed to manipulate micro-sized particles that can enhance particle trapping through the resonance interaction of acoustic waves with high Q factor (>3000), more than 20 times greater than traditional acoustic transducers. Particles can be precisely manipulated within the RR by adjusting the signal phase, with trapping amplified by enlarging the connected waveguide. Rapid particle mixing is achieved when particles are placed between the waveguide and RR. The signal path is strengthened by strategically positioning the RR in a two-dimensional plane. Acoustofluidic RR tweezers have immense potential for advancing applications in biosensing, mechanobiology, lab-on-a-chip, and cell-cell communication research.

中文翻译:


通过环形共振的声流体镊子



环形谐振器 (RR) 器件是闭环波导,其中波仅在谐振频率下循环。它们已用于传感器技术和光镊,但由于力不足、工作距离短和光损伤,使用光学 RR 镊子控制微米级颗粒具有挑战性。为了克服这些障碍,开发了一种基于声流体 RR 的镊子方法来操纵微粒,这些粒子可以通过高 Q 因子 (>3000) 的声波的共振相互作用来增强粒子捕获,其比传统声换能器大 20 倍以上。通过调整信号相位,可以在 RR 内精确操纵粒子,并通过扩大连接的波导来放大俘获。当颗粒放置在波导和 RR 之间时,可实现快速颗粒混合。通过将 RR 战略性地定位在二维平面上来加强信号路径。声流体 RR 镊子在推进生物传感、机械生物学、芯片实验室和细胞间通讯研究方面具有巨大潜力。
更新日期:2024-11-13
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