The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused more than 7 million deaths globally. Despite the presence of infection- and vaccine-induced immunity, SARS-CoV-2 infections remain a major global health concern because of the emergence of SARS-CoV-2 variants that can cause severe acute coronavirus disease 2019 (COVID-19) or enhance Long Covid disease phenotypes. About 5 to 10% of SARS-CoV-2–infected individuals develop Long Covid, which, similar to acute COVID 19, often affects the lung. However, Long Covid can also affect other peripheral organs, especially the brain. The causal relationships between acute disease phenotypes, long-term symptoms, and involvement of multiple organ systems remain elusive, and animal model systems mimicking both acute and post-acute phases are imperative. Here, we review the current state of Long Covid animal models, including current and possible future applications.

中文翻译：

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Long Covid 的动物模型：一种肇事逃逸的疾病


严重急性呼吸系统综合症冠状病毒 2 （SARS-CoV 2） 大流行已导致全球超过 700 万人死亡。尽管存在感染和疫苗诱导的免疫力，但由于 SARS-CoV-2 变体的出现，SARS-CoV-2 感染仍然是一个主要的全球健康问题，这些变体可导致 2019 年严重急性冠状病毒病 （COVID-19） 或增强长期 Covid 疾病表型。大约 5% 到 10% 的 SARS-CoV-2 感染者会发展为长期 Covid，这与急性 COVID 19 类似，通常会影响肺部。然而，Long Covid 也会影响其他外周器官，尤其是大脑。急性疾病表型、长期症状和多器官系统受累之间的因果关系仍然难以捉摸，模拟急性期和急性期后的动物模型系统势在必行。在这里，我们回顾了 Long Covid 动物模型的现状，包括当前和未来可能的应用。