Multifunctional Conjugated Polymer Nanoparticles for Image‐Guided Photodynamic and Photothermal Therapy,Small

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Multifunctional Conjugated Polymer Nanoparticles for Image‐Guided Photodynamic and Photothermal Therapy
Small ( IF 13.0 ) Pub Date : 2016-11-07 , DOI: 10.1002/smll.201602807
Guangxue Feng ₁ , Yuan Fang ₂ , Jie Liu ₁ , Junlong Geng ₁ , Dan Ding ₂ , Bin Liu _{1,

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Affiliation

A multifunctional theranostic platform based on conjugated polymer nanoparticles (CPNs) with tumor targeting, fluorescence detection, photodynamic therapy (PDT), and photothermal therapy (PTT) is developed for effective cancer imaging and therapy. Two conjugated polymers, poly[9,9‐bis(2‐(2‐(2‐methoxyethoxy)ethoxy)‐ethyl)fluorenyldivinylene]‐alt‐4,7‐(2,1,3‐benzothiadiazole) with bright red emission and photosensitizing ability and poly[(4,4,9,9‐tetrakis(4‐(octyloxy)phenyl)‐4,9‐dihydro‐s‐indacenol‐dithiophene‐2,7‐diyl)‐alt‐co‐4,9‐bis(thiophen‐2‐yl)‐6,7‐bis(4‐(hexyloxy)phenyl)‐thiadiazolo‐quinoxaline] with strong near‐infrared absorption and excellent photothermal conversion ability are co‐loaded into one single CPN via encapsulation approach using lipid‐polyethylene glycol as the matrix. The obtained co‐loaded CPNs show sizes of around 30 nm with a high singlet oxygen quantum yield of 60.4% and an effective photothermal conversion efficiency of 47.6%. The CPN surface is further decorated with anti‐HER2 affibody, which bestows the resultant anti‐HER2‐CPNs superior selectivity toward tumor cells with HER2 overexpression both in vitro and in vivo. Under light irradiation, the PDT and PTT show synergistic therapeutic efficacy, which provides new opportunities for the development of multifunctional biocompatible organic materials in cancer therapy.

中文翻译：

用于图像引导的光动力和光热疗法的多功能共轭聚合物纳米颗粒

开发了一种基于共轭聚合物纳米颗粒（CPN），具有靶向肿瘤，荧光检测，光动力疗法（PDT）和光热疗法（PTT）的多功能治疗疗法平台，用于有效的癌症成像和治疗。两个共轭聚合物，聚[9,9-双（2-（2-（2-甲氧基乙氧基）乙氧基） -乙基）fluorenyldivinylene] - ALT -4,7-（2,1,3-苯并噻二唑）与明亮的红色发射和光敏能力和聚[（4,4,9,9-四（4-（辛氧基））苯基）-4,9-二氢-s-茚满醇-二噻吩-2,7-二基）-alt -co具有强大的近红外吸收能力和出色的光热转换能力的‐4,9-双（噻吩-2-基）-6,7-双（4-（己氧基）苯基）噻二唑并喹喔啉]共装入一个样品中通过使用脂质-聚乙二醇为基质的包封方法进行CPN。所获得的共载CPN的尺寸约为30 nm，单线态氧量子产率高，为60.4％，有效的光热转换效率为47.6％。CPN表面进一步用抗-HER2亲和素修饰，这赋予了所得的抗-HER2-CPNs对肿瘤细胞具有优异的选择性，无论其在体内还是体外均具有HER2过表达。在光照射下，PDT和PTT显示出协同的治疗功效，这为癌症治疗中多功能生物相容性有机材料的开发提供了新的机会。

更新日期：2016-11-07

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