Myopia can impact an individual’s quality of life and induce multiple complications. In this study, we randomly divided guinea pigs into the normal control (NC) group, the lens-induced myopia (LIM) group, the normal control plus l-arginine injection (l-Arg) group, and the normal control plus saline injection (NaCl) group. The animals in each group received the relevant treatments. The results showed that myopia was deeper in the LIM and l-Arg groups compared with the NC and NaCl groups. Our experimental results suggest that the excessive supplement of l-Arg will induce myopia onset and a MEK-ERK cascade that stimulates the downstream nNOS-MMP2 and NRF2-KEAP1 signaling pathways, which is accompanied by inflammatory responses, fibrosis changes, and oxidative stress. After receiving excessive arginine supplements, the experimental individuals showed myopic shifts and a similar pathological state as the LIM group. In conclusion, the supplement of excessive arginine may be a danger factor for myopia onset.

中文翻译：

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过量补充 l-精氨酸通过编排 MEK-ERK-NO 信号通路诱导近视


近视会影响个人的生活质量并诱发多种并发症。在本研究中，我们将豚鼠随机分为正常对照组 （NC） 、晶状体诱导近视 （LIM） 组、正常对照组加 l-精氨酸注射液 （l-Arg） 组和正常对照组加生理盐水注射液 （NaCl） 组。每组动物接受相关治疗。结果显示，与 NC 和 NaCl 组相比，LIM 和 l-Arg 组的近视更深。我们的实验结果表明，过量补充 l-Arg 会诱导近视发作和 MEK-ERK 级联反应，刺激下游 nNOS-MMP2 和 NRF2-KEAP1 信号通路，并伴有炎症反应、纤维化变化和氧化应激。在接受过量的精氨酸补充剂后，实验个体表现出近视变化和与 LIM 组相似的病理状态。总之，补充过量的精氨酸可能是近视发作的危险因素。