INTRODUCTIONIn a nested case–control study, we examined how cerebral perfusion relates to cognitive status and amyloid in the oldest‐old (i.e., 90 years of age and older).METHODSStudy participants included 113 dementia‐free older adults (76 cognitively normal [CN]; 37 cognitively impaired, no dementia [CIND]) from the 90+ Study (mean age = 92.9, SD = 2.4). We quantified regional perfusion from arterial spin labeling‐MRI (magnetic resonance imaging) and amyloid deposition from florbetapir‐positron emission tomography (PET) in a region comprising the posterior cingulate and precuneus (PCC+PCu), and additionally quantified perfusion in other regions important for cognitive decline (medial temporal lobe, inferior parietal lobe, and orbitofrontal cortex).RESULTSParticipants with CIND displayed lower perfusion in the PCC+PCu relative to participants who were CN, but there was no statistically significant difference between the groups in amyloid burden in this region. In addition, participants with CIND exhibited lower inferior parietal and higher orbitofrontal perfusion.DISCUSSIONCerebral perfusion is related to cognitive status in the oldest‐old independent of amyloidosis.Highlights Cerebral perfusion and amyloid positron emission tomography (PET) were measured in older adults: 90 years of age and older. Perfusion but not amyloid differed between cognitively impaired and normal groups. Frontal and parietal regions linked to cognitive decline had altered perfusion. Perfusion is related to cognitive status in the oldest‐old independent of amyloid.

中文翻译：

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最年长老年人的脑灌注和淀粉样变性


引言在一项嵌套病例对照研究中，我们检查了脑灌注与最年长老年人（即 90 岁及以上）的认知状态和淀粉样蛋白的关系。方法研究参与者包括来自 90+ 研究的 113 名无痴呆老年人 （76 名认知正常 [CN];37 名认知障碍，无痴呆 [CIND]） （平均年龄 = 92.9，SD = 2.4）。我们量化了动脉自旋标记-MRI （磁共振成像） 的区域灌注和来自后扣带回和楔前叶 （PCC+PCu） 的区域 florbetapir-正电子发射断层扫描 （PET） 的淀粉样蛋白沉积，并额外量化了其他对认知能力下降很重要的区域 （内侧颞叶、下顶叶和眶额叶皮层） 的灌注。结果相对于 CN 的参与者，具有 CIND 的参与者在 PCC+PCu 中的灌注较低，但该区域的淀粉样蛋白负荷组间无统计学意义差异。此外，CIND 参与者表现出较低的下顶叶和较高的眶额灌注。讨论大脑灌注与最年长者的认知状态有关，与淀粉样变性无关。亮点 在老年人中测量脑灌注和淀粉样蛋白正电子发射断层扫描 （PET）：90 岁及以上。灌注但无淀粉样蛋白在认知障碍组和正常组之间存在差异。与认知能力下降相关的额叶和顶叶区域灌注发生了变化。灌注与最年长者的认知状态相关，与淀粉样蛋白无关。