Section snippets

Financial support

Funded by the National Cancer Institute Intramural Research Program.

Declaration of Competing Interest

The authors declare no conflicts of interest that pertain to this work.Please refer to the accompanying ICMJE disclosure forms for further details.Adipose triglyceride lipase (ATGL), encoded by the PNPLA2 gene in humans, hydrolyzes triacylglycerols to diacylglycerols. PNPLA2 is regulated by insulin, and under conditions of insulin resistance, increased adipocyte ATGL leads to excess production of free fatty acids that are transported to the liver resulting in metabolic dysfunction-associated

中文翻译：

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脂肪甘油三酯脂肪酶作为治疗代谢功能障碍相关脂肪性肝炎的靶点：肝和肠道 PPARα 的作用

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 财务支持

由美国国家癌症研究所校内研究计划资助。

利益争夺声明

作者声明不存在与本作品相关的利益冲突。有关更多详细信息，请参阅随附的 ICMJE 披露表。脂肪甘油三酯脂肪酶 （ATGL） 由人类 PNPLA2 基因编码，可将三酰基甘油水解为甘油二酯。PNPLA2 受胰岛素调节，在胰岛素抵抗条件下，脂肪细胞 ATGL 增加导致游离脂肪酸产生过多，这些游离脂肪酸被转运到肝脏，从而导致代谢功能障碍相关