Herein, we disclose a simple one-pot method for an efficient regio- and stereoselective synthesis of 1,3,5-triaroylcyclohexanes from aryl vinyl ketones using potassium tert-butoxide. The developed protocol allows the construction of various symmetrically substituted cyclohexanes in good to excellent yields. The major product 2 also can be converted to the product 3 (all equatorial) conveniently by acid catalysis. This protocol features a good substrate scope and functional group compatibility.

中文翻译：

---

通过 KOtBu 介导的芳基乙烯基酮的环三聚化构建 1,3,5-三羟基环己烷的区域选择性和立体选择性构建


在此，我们公开了一种简单的一锅法，用于使用叔丁醇钾从芳基乙烯基酮高效区域和立体选择性合成 1,3,5-三羟基环己烷。开发的方案允许构建各种对称取代的环己烷，产量从好到极好。主要产物 2 也可以方便地通过酸催化转化为产物 3（均为赤道）。该协议具有良好的底物范围和官能团兼容性。