A rhodaelectro-catalyzed double dehydrogenative Heck reaction of indole-2-carboxylic acids with alkenes has been developed for the synthesis of pyrano[3,4-b]indol-1(9H)-ones. The weakly coordinating carboxyl group is utilized twice as a directing group to activate the C–H bonds throughout the reaction. This reaction precedes an acceptorless dehydrogenation under exogenous oxidant-free conditions in an undivided cell with a constant current.

中文翻译：

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通过吲哚-2-羧酸和烯烃之间的双重脱氢 Heck 反应，罗达电催化合成吡哒[3,4-b]吲哚-1（9H）-酮


已经开发了一种吲哚-2-羧酸与烯烃的电催化双脱氢 Heck 反应，用于合成吡喃[3,4-b]吲哚-1（9H）-酮。弱配位的羧基被用作定向基团两次，以在整个反应过程中激活 C-H 键。该反应在无外源性氧化剂条件下，在恒定电流的未分流池中进行无受体脱氢之前。