This study describes a general method for the preparation of 1,4-oxazin-2-one intermediates from acetylene dicarboxylate and β-amino alcohol precursors. Oxazinones prepared in this manner were employed in a tandem cycloaddition/cycloreversion reaction sequence with a model alkyne (phenyl acetylene) to give substituted pyridine products. Fundamental reactivity and selectivity studies are complemented by the synthesis of the polycyclic ergot alkaloid natural product xylanigripone A.

中文翻译：

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来自 1,4-恶嗪酮前体的多取代吡啶


本研究描述了一种从乙炔二羧酸盐和 β-氨基醇前体制备 1,4-恶嗪-2-酮中间体的通用方法。以这种方式制备的恶嗪酮与模型炔烃（苯基乙炔）在串联环加成/环反转反应序列中用于得到取代的吡啶产物。基本反应性和选择性研究由多环麦角生物碱天然产物二基苯醚 A 的合成补充。