γ-Lactams are important core structure found in various natural and biologically active compounds. And the introducing of difluoromethylene group into a molecule can change its physical, chemical, and biological properties. As carbonylation chemistry represent a powerful and efficient method for the synthesis of carbonylated compounds, we report here an efficient procedure for the construction of difluoroalkylative γ-lactams via palladium-catalyzed carbonylative cyclization of alkenes. The desired γ-lactams were produced in moderate to good yields under relatively mild conditions.

中文翻译：

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钯催化的未活化烯烃对 γ-内酰胺的二氟烷基化反应


γ-内酰胺是存在于各种天然和生物活性化合物中的重要核心结构。将二氟亚甲基引入分子中可以改变其物理、化学和生物性质。由于羰基化化学代表了一种强大而有效的合成羰基化化合物的方法，我们在这里报告了一种通过钯催化的烯烃羰基化环化构建二氟烷基化γ-内酰胺的有效方法。在相对温和的条件下，以中等至良好的产量生产所需的 γ-内酰胺。