The catalytic cycloisomerization of nucleophile-functionalized alkynes is a useful method for the synthesis of heterocyclic compounds with 100% atom economy. Group 8 catalysts give high endo-selectivity in these transformations due to their ability to invoke metal-vinylidene intermediates. However, all known group 8 catalysts have relatively low activities and require high temperatures. Here, we report bifunctional ruthenium catalysts that enable the cycloisomerization of a large variety of substrates at low catalyst loadings and ambient temperature with turnover frequencies as high as 200 s^–1.

中文翻译：

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用于亲核功能化末端炔烃内选择性环异构化的双功能钌催化剂


亲核官能化炔烃的催化环异构化是合成杂环化合物的有用方法，具有 100% 的原子经济性。第 8 组催化剂在这些转化中具有很高的内选择性，因为它们能够调用金属 - 偏二乙烯中间体。然而，所有已知的第 8 族催化剂都具有相对较低的活性，并且需要高温。在这里，我们报道了双功能钌催化剂，它们能够在低催化剂负载量和环境温度下对各种基材进行环异构化，周转频率高达 200 ^s-1。