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Glymphatic dysfunction in PD clinical progression
Nature Reviews Neurology ( IF 28.2 ) Pub Date : 2024-11-13 , DOI: 10.1038/s41582-024-01040-z Lisa Kiani
中文翻译:
PD 临床进展中的淋巴功能障碍
更新日期:2024-11-13
Nature Reviews Neurology ( IF 28.2 ) Pub Date : 2024-11-13 , DOI: 10.1038/s41582-024-01040-z Lisa Kiani
Risk of clinical milestones in Parkinson disease (PD) is associated with reduced glymphatic drainage, according to new research. The study of 175 people with PD showed that lower glymphatic function, measured by diffusion tensor imaging analysis of the perivascular space, was associated with increased risk of recurrent falls, wheelchair dependence and dementia. The study adds to growing evidence for a role of the glymphatic system in PD pathology that warrants further investigation.
中文翻译:
PD 临床进展中的淋巴功能障碍
根据新的研究,帕金森病 (PD) 临床里程碑的风险与淋巴引流减少有关。对 175 名 PD 患者的研究表明,通过血管周围间隙弥散张量成像分析测量的较低淋巴功能与复发性跌倒、轮椅依赖和痴呆的风险增加有关。该研究增加了越来越多的证据,证明淋巴系统在 PD 病理学中的作用值得进一步研究。