Nature Reviews Neurology ( IF 28.2 ) Pub Date : 2024-11-13 , DOI: 10.1038/s41582-024-01039-6 Lisa Kiani
A recent analysis of dementia risk scores across diverse populations found that the validity of scores can differ between ethnic groups. The widely investigated Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score, which estimates 20-year dementia risk at midlife on the basis of age, sex, education, systolic blood pressure, body mass index, cholesterol level and physical activity, was compared with a modified version (mCAIDE) that includes self-reported information on sociodemographic characteristics, personal and family medical history and mood. Higher CAIDE scores were associated with increased risk of dementia in non-Latinx White, Latinx, and Asian Americans, but not Black Americans, whereas mCAIDE scores were associated with risk in all groups. The findings highlight the need to evaluate and revise risk score methods to suit the specific racial and ethnic make-up of the studied population.
中文翻译:
不同人群的痴呆风险评分
最近对不同人群的痴呆风险评分的分析发现,分数的有效性可能因种族群体而异。广泛调查的心血管危险因素、衰老和痴呆症发病率 (CAIDE) 风险评分,该评分根据年龄、性别、教育程度、收缩压、体重指数、胆固醇水平和身体活动估计中年 20 年痴呆风险,与修改版 (mCAIDE) 进行了比较,后者包括有关社会人口学特征、个人和家族病史和情绪的自我报告信息。较高的 CAIDE 评分与非拉丁裔白人、拉丁裔和亚裔美国人的痴呆风险增加相关,但与美国黑人无关,而 mCAIDE 评分与所有组的风险相关。研究结果强调需要评估和修订风险评分方法,以适应研究人群的特定种族和民族构成。