Movies captivate groups of individuals (the audience), especially if they contain themes of common motivational interest to the group. In drug addiction, a key mechanism is maladaptive motivational salience attribution whereby drug cues outcompete other reinforcers within the same environment or context. We predicted that while watching a drug-themed movie, where cues for drugs and other stimuli share a continuous narrative context, fMRI responses in individuals with heroin use disorder (iHUD) will preferentially synchronize during drug scenes. Thirty inpatient iHUD (24 male) and 25 healthy controls (16 male) watched a drug-themed movie at baseline and at follow-up after 15 weeks. Results revealed such drug-biased synchronization in the orbitofrontal cortex (OFC), ventromedial and ventrolateral prefrontal cortex, and insula. After 15 weeks during ongoing inpatient treatment, there was a significant reduction in this drug-biased shared response in the OFC, which correlated with a concomitant reduction in dynamically-measured craving, suggesting synchronized OFC responses to a drug-themed movie as a neural marker of craving and recovery in iHUD.

中文翻译：

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与毒品主题电影共享的眼眶额叶动力学，记录海洛因成瘾的渴望和恢复


电影吸引了一群人（观众），特别是当它们包含对该群体具有共同动机兴趣的主题时。在药物成瘾中，一个关键机制是适应不良的动机显著性归因，即在相同的环境或环境中，药物线索胜过其他强化因素。我们预测，在观看一部以毒品为主题的电影时，毒品和其他刺激的线索共享一个连续的叙事背景，海洛因使用障碍 （iHUD） 患者的 fMRI 反应将在毒品场景中优先同步。30 名住院 iHUD （24 名男性） 和 25 名健康对照 （16 名男性） 在基线和 15 周后的随访中观看了一部以药物为主题的电影。结果显示，眶额叶皮层 （OFC） 、腹内侧和腹外侧前额叶皮层以及岛叶存在这种药物偏倚的同步。在持续的住院治疗期间 15 周后，OFC 中这种药物偏倚的共享反应显着减少，这与动态测量的渴望的减少相关，表明 OFC 对药物主题电影的同步反应作为 iHUD 中渴望和恢复的神经标志物。