We developed a translational prototype antimicrobial blue light (ABL) device for treating skin wounds with ABL. Partial-thickness surgical wounds were created in live swine, an animal whose skin is considered the most like human skin, then heavily contaminated and left untreated for 24 hours with methicillin-resistant Staphylococcus aureus (MRSA). ABL treatment stabilized and reduced MRSA infection by greater than four orders of magnitude (>99.99%; p<0.0001) compared with untreated wounds in the same animal, after only two daily treatments. These data support further development of such devices for controlling infection in skin wounds. ABL, with or without concomitant administration of negative pressure, antimicrobials, or photosensitizers, could play an important role in modern wound care by reducing the amount, duration, and cost of antibiotics needed, helping reduce AMR. No such device for treating human cutaneous wounds currently exists. This deserves further development and study.

中文翻译：

---

抗菌蓝光原型装置在临床前猪模型中控制感染的伤口


我们开发了一种转化原型抗菌蓝光 （ABL） 设备，用于用 ABL 治疗皮肤伤口。在活猪身上制造部分厚度的手术伤口，这种动物的皮肤被认为最像人类皮肤，然后被严重污染并放置 24 小时未处理耐甲氧西林金黄色葡萄球菌 （MRSA）。与同一只动物未治疗的伤口相比，ABL 治疗仅经过两次每日治疗，即可稳定并减少 MRSA 感染超过 4 个数量级 （>99.99%;p<0.0001）。这些数据支持进一步开发用于控制皮肤伤口感染的此类设备。ABL 联合或不联合负压、抗菌剂或光敏剂，可以通过减少所需抗生素的数量、持续时间和成本，帮助减少 AMR，在现代伤口护理中发挥重要作用。目前没有这种治疗人类皮肤伤口的设备。这值得进一步发展和研究。