Oxidant-free gold-catalyzed reactions are emerging as a novel synthetic tool for organic transformations. Herein, we report a hemilabile P,N-ligand-assisted gold-catalyzed Hiyama cross coupling reaction of aryl and alkenyl iodides with allylsilanes. The reaction proceeds smoothly without an external oxidant under mild conditions, providing access to a series of allylarenes and 1,4-diene derivatives in good to excellent yields. This transformation features a broad substrate scope, good functional group tolerance, and compatibility with heteroaromatic substrates. The (P,N) ligand MeDalphos-facilitated gold-catalyzed process presents a new approach for the synthesis of allylarenes and 1,4-diene derivatives. Moreover, mechanistic investigations including NMR and mass spectrometric studies strongly support the proposed mechanism of the reaction.

中文翻译：

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Hemilabile P，N-配体辅助金催化 Hiyama 烯丙基化以获得烯丙烯和 1,4-二烯衍生物


无氧化剂金催化反应正在成为一种新型的有机转化合成工具。在此，我们报道了芳基和烯基碘化物与烯基硅烷的半 P，N-配体辅助金催化的 Hiyama 交叉偶联反应。在温和的条件下，在没有外部氧化剂的情况下，反应顺利进行，以良好到极好的收率获得一系列烯丙烯和 1,4-二烯衍生物。这种转化具有广泛的底物范围、良好的官能团耐受性以及与杂芳烃底物的相容性。（P，N） 配体 MeDalphos 促进的金催化工艺为烯丙烯和 1,4-二烯衍生物的合成提供了一种新方法。此外，包括 NMR 和质谱研究在内的机理研究强烈支持所提出的反应机理。